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Women were also mailed a gift-wrapped package which they were instructed to not open until directed to do so by the interventionist. CEA is a substance in the blood that may be increased when cancer is present. Within 4 weeks of trial entry, patients underwent clinical evaluation history, physical examination, ECOG performance status assessment, neurological examination as well as digital rectal examination, sigmoidoscopy and tumour biopsy. Liver and extra-pelvic lymph node. Open in a separate window. Results The intervention had medium effect sizes from baseline to follow-up 1, which decreased by follow-up 2. The improved pathological response rates in favour of oxaliplatin here may reflect the lower RT dose Gerard et al, or inadequate 5-FU backbone Rodel et al, in the control arms of these studies.